Fadia Ibrahim

Research Associate

My primary research project is focused on understanding the role of RNA dysregulation in two neurodegenerative diseases, Amyotrophic lateral sclerosis (ALS) and Frontotemporal lobar degeneration (FTLD). To unravel the molecular mechanism of neuronal degeneration, I am studying the role of RNA-binding proteins in disease pathogenesis. I am also developing a high-throughput sequencing protocol to understand the mechanism of RNA processing in the normal context and in diseased neurons. My previous research experiences covered several areas in molecular biology, biochemistry, cancer biology and microbiology fields. My PhD. studies focused on understanding the molecular pathway of RNA interference (RNAi). My studies led to the discovery of a novel enzyme of the RNAi pathway required for target mRNA degradation. I also uncovered a novel quality control mechanism to eliminate dysfunctional small RNA molecules. Understanding the role of RNA metabolism alterations in ALS/FTLD pathogenesis may lead to therapies for these fatal diseases.


Email: ifadia@mail.med.upenn.edu